Figure 2
From: Self-organizing actin waves that simulate phagocytic cup structures
Spatial organization of actin waves and the temporal pattern of actin polymerization and depolymerization. Left panel: schematic cross-section through an actin wave showing the region at the front and close to the membrane where myosin-IB is enriched (green) and the sloping roof of the wave to which coronin is recruited (yellow). Vertical arrows indicate up and down regulation of actin polymerization. Data suggest two gradients of actin polymerization, one falling from the substrate-attached membrane to the top of the wave, the other from its front to the tail. Right panel: translation of the spatial profile into a temporal sequence of actin net polymerization and depolymerization. The profile illustrates the sequence of changes that occur when a wave passes over a point on the membrane. The data published in [4] suggest that an initial phase of high-rate actin polymerization turns into a longer phase of depolymerization.