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Figure 14 | PMC Biophysics

Figure 14

From: Monte Carlo Simulations indicate that Chromati: Nanostructure is accessible by Light Microscopy

Figure 14

This figure shows the interaction frequency of different fiber parts with the center of the chromatin fiber in dependence of the distance to the center. Interactions on the kbp scale are genetically very important for instance to allow enhancers and promotors to come into close proximity to one another. The comparison shows simulation results of chromatin with and without histone depletion as well as results from 5C-experiments of a gene desert on chromosome 16 [59]. The distributions of the simulated chromatin fibers without histone depletion are much to broad to match the experimental data. The fibers would be genetically inactive. The distributions of the simulated fibers with histone depletions show at least a qualitative match of the experimental data. These fibers are genetically active

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