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Table 1 Amino acid residues at the inter-subunit interfaces of the pre-pore Cry4Aa trimer

From: Combined molecular dynamics and continuum solvent studies of the pre-pore Cry4Aa trimer suggest its stability in solution and how it may form pore

Percentage of time in contact Helix α2 (res95-126) of monomer Mi Helix α3 (res130-157) of monomer Mi Helix α4 (res169-191) of monomer Mi+1 Helix α6 (res249-276) of monomer Mi+1
Group 1   Lys139 Thr172 Leu243b
~100% or morea   Asn142 Gln175 Pro244b
   Arg143 Leu176 Thr245b
   Asn146 Tyr179 Ala246b
   Val147 His180 Ile247b
   Thr150 Gln182  
    Asn183  
    Pro186  
    Glu187  
    Asn190  
    Ser191  
Group 2     
  Asp109 Thr132 Thr167 Glu241b
  Gln110 Ser135 Asp169 Pro242b
more than 70% but less than 100%   Asn136 Gln173 Asp248b
   Asn138 His178 Pro251
   Asn153 Val189 Val252
   His154 Pro194 c Lys255
  1. Two groups of amino acid residues located at the inter-subunit interface of Cry4Aa monomers Mi and Mi+1 in Cry4Aa trimer where i and i+1 run in cyclic of 1, 2, and 3. aThe percentage of more than 100% was due to some residues were counted more than once because they were within two or more inter-subunit interfaces of Cry4Aa trimer. bResidues on the loop between α5 and α6. cResidue on the loop between α4 and α5.