Table 3 Fractions of stable mutants (< 1 kT) from codons 96 to 289 before and after substitution.
From: Structural and functional implications of p53 missense cancer mutations
G | A | V | L | I | S | C | T | M | F | Y | W | H | K | R | D | E | N | Q | ALL | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A | 2/4 | 5/6 | 3/4 | 6/7 | 0/1 | 3/7 | 0.655 | |||||||||||||
V | 1/12 | 1/12 | 6/12 | 5/6 | 1/8 | 1/5 | 0/3 | 2/5 | 0/9 | 0.24 | ||||||||||
L | 5/9 | 2/3 | 1/1 | 1/5 | 3/6 | 1/4 | 1/8 | 0/6 | 0.33 | |||||||||||
I | 0/6 | 3/4 | 0/6 | 0/6 | 1/3 | 0/6 | 0/1 | 0/1 | 0/6 | 0.10 | ||||||||||
S | 7/7 | 3/3 | 1/2 | 4/5 | 11/11 | 10/10 | 6/7 | 1/3 | 0/1 | 4/6 | 3/5 | 0.67 | ||||||||
C | 1/8 | 0/1 | 3/10 | 1/1 | 0/7 | 2/9 | 0/8 | 0/1 | 1/10 | 0/1 | 0.14 | |||||||||
T | 9/10 | 9/11 | 3/8 | 2/3 | 3/5 | 1/2 | 3/6 | 0.67 | ||||||||||||
M | 5/6 | 4/5 | 5/6 | 2/5 | 1/6 | 1/4 | 0.56 | |||||||||||||
F | 0/1 | 1/4 | 1/5 | 1/3 | 1/5 | 0/4 | 2/2 | 0.25 | ||||||||||||
Y | 0/1 | 0/6 | 0/6 | 5/5 | 0/7 | 0/1 | 0/7 | 0/6 | 0/1 | 0.125 | ||||||||||
W | 0/1 | 0/1 | 0/1 | 0/1 | 0/1 | 0.0 | ||||||||||||||
H | 1/1 | 3/5 | 5/7 | 2/6 | 2/6 | 2/4 | 3/6 | 0.51 | ||||||||||||
K | 1/1 | 3/3 | 2/3 | 0/1 | 4/5 | 2/4 | 3/4 | 2/3 | 0.71 | |||||||||||
R | 3/15 | 11/12 | 1/3 | 4/13 | 5/9 | 2/4 | 1/2 | 0/1 | 1/2 | 0/6 | 5/10 | 3/4 | 0/2 | 3/8 | 0.43 | |||||
D | 3/7 | 3/3 | 6/8 | 1/1 | 5/8 | 4/7 | 0/1 | 6/7 | 7/8 | 0.70 | ||||||||||
E | 4/11 | 6/9 | 8/10 | 1/2 | 4/11 | 0/1 | 6/10 | 4/8 | 0.53 | |||||||||||
N | 7/8 | 8/9 | 7/7 | 1/1 | 0/1 | 2/6 | 3/6 | 4/6 | 6/8 | 0.73 | ||||||||||
Q | 3/5 | 5/6 | 3/4 | 5/6 | 2/2 | 0.78 | ||||||||||||||
ALL | 0.31 | 0.58 | 0.62 | 0.63 | 0.76 | 0.365 | 0.52 | 0.74 | 0.36 | 0.38 | 0.47 | 0.0 | 0.44 | 0.47 | 0.38 | 0.43 | 0.45 | 0.43 | 0.375 |