Table 2 Fractions of unstable mutants (> 3 kT) from codons 96 to 289 before and after substitution.

A

0/4

1/6

0/4

1/7

1/1

3/7

0.21

V

10/12

7/12

6/12

1/6

6/8

3/5

3/3

3/5

9/9

0.67

L

0/9

0/3

0/1

0/5

3/6

2/4

6/8

4/6

0.36

I

0/6

1/4

6/6

6/6

1/3

6/6

1/1

1/1

6/6

0.72

S

0/7

0/3

1/2

1/5

0/11

0/10

1/7

2/3

1/1

2/6

1/5

0.15

C

5/8

0/1

4/10

0/1

6/7

7/9

7/8

1/1

9/10

0/1

0.70

T

0/10

2/11

0/8

1/3

1/5

1/2

0/6

0.11

M

0/6

1/5

1/6

2/5

4/6

3/4

0.34

F

1/1

2/4

3/5

1/3

4/5

4/4

0/2

0.625

Y

1/1

6/6

6/6

0/5

7/7

1/1

7/7

6/6

1/1

0.875

W

1/1

0/1

1/1

0/1

1/1

0.60

H

0/1

2/5

2/7

4/6

1/6

1/4

2/6

0.34

K

0/1

0/3

0/3

1/1

1/5

1/4

0/4

1/3

0.17

R

3/15

0/12

1/3

2/13

0/9

2/4

0/2

1/1

1/2

6/6

3/10

1/4

1/2

3/8

0.26

D

0/7

0/3

1/8

0/1

2/8

2/7

1/1

0/7

0/8

0.12

E

2/11

0/9

0/10

0/2

5/11

1/1

1/10

1/8

0.16

N

1/8

0/9

0/7

0/1

1/1

3/6

2/6

0/6

1/8

0.15

Q

2/5

1/6

0/4

0/6

0/2

0.13

ALL

0.34

0.18

0.08

0.30

0.17

0.365

0.32

0.26

0.32

0.56

0.47

0.94

0.44

0.34

0.58

0.39

0.45

0.36

0.375