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Table 1 Highly stable mutations (ΔΔG ≤ -3 kT) and their predicted relative stabilities by PBSA, DFIRE, and FOLDX, respectively.

From: Structural and functional implications of p53 missense cancer mutations

MUTANTS SEC. ΔΔG (PBSA) ΔΔG (DFIRE) ΔΔG (FOLDX) No. CASE.
A159V S4 -2.27 -1.83 -1.49 41
A161V S4 -3.51 -1.98 -1.14 12
N235I S8 -2.85 -1.68 -2.04 5
N239Y L3 -2.36 -2.41 -2.17 8
T256I S9 -1.22 -1.96 -1.84 3
S269I S10 -1.95 -1.99 -0.91 1
  1. The unit of ΔΔG is in kcal/mol. Second column shows secondary structure elements. The last column gives the number of reported cases in the IARC database.