Table 1 Highly stable mutations (ΔΔG ≤ -3 kT) and their predicted relative stabilities by PBSA, DFIRE, and FOLDX, respectively.
From: Structural and functional implications of p53 missense cancer mutations
MUTANTS | SEC. | ΔΔG (PBSA) | ΔΔG (DFIRE) | ΔΔG (FOLDX) | No. CASE. |
|---|---|---|---|---|---|
A159V | S4 | -2.27 | -1.83 | -1.49 | 41 |
A161V | S4 | -3.51 | -1.98 | -1.14 | 12 |
N235I | S8 | -2.85 | -1.68 | -2.04 | 5 |
N239Y | L3 | -2.36 | -2.41 | -2.17 | 8 |
T256I | S9 | -1.22 | -1.96 | -1.84 | 3 |
S269I | S10 | -1.95 | -1.99 | -0.91 | 1 |