Figure 1

Stability distribution of IARC missense mutations from codons 96 to 289. Symbols in Italic Times: wild type amino acids; those in Normal Times: mutant amino acids; and those in Bold Times: secondary structures. Red grids: mutations with relative stabilities larger than 3 kT (including clash and Zinc-binding). Blue grids: mutations with relative stabilities less than 1 kT. Grey grids: mutations with relative stabilities between 1 kT and 3 kT. Mauve grids: mutations from or to PRO and from GLY. Yellow grids: mutations without consistent predictions.