Table 2 Comet-forming activities of organotin(IV) derivatives

1 Bu ₃ Sn(L1)

CTL (μm)

38.7 ± 1.4

49.5 ± 2.0***

50.1 ± 1.7***

40.9 ± 1.8

47.6 ± 1.6***

% T DNA

1.5 ± 0.4

4.4 ± 0.9***

7.4 ± 1.5***

9.9 ± 1.2***

4.7 ± 1.0***

OTM

0.3 ± 0.1

1.3 ± 0.4***

2.1 ± 0.6***

2.0 ± 0.4***

1.4 ± 0.5***

2 BuSnCl(L1) ₂

CTL (μm)

29.7 ± 0.9

39.5 ± 1.1***

40.7 ± 1.2***

38.3 ± 1.1***

44.7 ± 1.4***

% T DNA

1.8 ± 0.5

7.6 ± 1.4***

6.5 ± 0.3***

8. 5 ± 1.4***

8.9 ± 1.6***

OTM

0.3 ± 0.1

1.5 ± 0.3***

1.4 ± 0.3***

1.6 ± 0.3***

2.1 ± 0.5***

3 Ph ₃ Sn(L1)

CTL (μm)

41.7 ± 2.3

52.9 ± 2.7***

51.1 ± 2.4***

48.9 ± 2.8***

56.8 ± 2.9***

% T DNA

3.5 ± 0.6

8.3 ± 1.4***

9.3 ± 1.4***

10.4 ± 1.7***

12.68 ± 1.8***

OTM

0.9 ± 0.2

2.8 ± 0.8***

2.7 ± 0.6***

3.5 ± 0.9***

4.0 ± 0.9***

4 Bu ₂ Sn(L1) ₂

CTL (μm)

29.7 ± 0.9

41.4 ± 1.0***

40.65 ± 1.1***

38.0 ± 1.1***

44.7 ± 1.4***

% T DNA

1.8 ± 0.5

7.0 ± 1.2***

7.55 ± 1.2***

6.2 ± 1.2***

8.9 ± 1.6***

OTM

0.3 ± 0.1

1.4 ± 0.3***

1.49 ± 0.3***

1.2 ± 0.2***

2.1 ± 0.5***

5 Et ₂ Sn(L2) ₂

CTL (μm)

33.7 ± 0.9

36.98 ± 1.1***

39.8 ± 1.3***

39.7 ± 1.1***

41.0 ± 1.5***

% T DNA

2.7 ± 0.7

4.91 ± 0.99**

6.2 ± 1.2***

6.3 ± 1.2***

7.1 ± 1.4***

OTM

0.5 ± 0.1

1.06 ± 0.3***

1.4 ± 0.3***

1.3 ± 0.3***

1.9 ± 0.5***

6 Me ₂ Sn(L2) ₂

CTL (μm)

30.2 ± 0.8

34.2 ± 1.1***

35.6 ± 1.2***

34.3 ± 1.0***

36.6 ± 1.2***

% T DNA

0.8 ± 0.3

4.8 ± 1.1***

6.5 ± 1.2***

4.5 ± 1.1***

4.6 ± 0. 9***

OTM

1.1 ± 0.04

1.0 ± 0.3***

1.4 ± 0.5***

0.9 ± 0.2***

1.0 ± 0.2***

7 Ph ₃ Sn(L2)

CTL (μm)

30.2 ± 0.8

35.9 ± 1.1***

37.8 ± 1.2*

32.4 ± 1.1*

36.6 ± 1.15***

% T DNA

0.8 ± 0.3

4.9 ± 1.1***

4.4 ± 1.2***

4.7 ± 1.1***

4.6 ± 0.9***

OTM

1.1 ± 0.04

1.0 ± 0.2***

1.2 ± 0.5***

0.9 ± 0.2***

1.0 ± 0.9***

8 Bu ₂ Sn(L2) ₂

CTL (μm)

41.7 ± 2.3

51.4 ± 2.4***

52.2 ± 2.4***

55.2 ± 2.9***

56.8 ± 3.0***

% T DNA

3.5 ± 0.6

8.9 ± 1.4***

8.6 ± 1.3***

9.4 ± 1.2***

12.6 ± 1.8***

OTM

0.9 ± 0.2

2.7 ± 0.6***

2.4 ± 0.5***

2.6 ± 0.5***

4.0 ± 0.9***

9 Bu ₂ Sn(L3) ₂

CTL (μm)

37.5 ± 1.2

40.5 ± 1.3

39.4 ± 1.5

34.5 ± 1.3*

50.0 ± 2.0***

% T DNA

3.9 ± 0.85

5.3 ± 1.0

6.2 ± 1.1*

5.8 ± 1.2*

9.0 ± 1.7***

OTM

0.8 ± 0.2

1.1 ± 0.4

1.5 ± 0.4*

1.2 ± 0.31*

3.2 ± 0.4***

10 BuSn(L3) ₃

CTL (μm)

38.7 ± 1.4

45.8 ± 1.7***

45.2 ± 1.4***

44.8 ± 1.6***

47.6 ± 1.6***

% T DNA

1.5 ± 0.4

5.0 ± 1.0***

5.2 ± 1.1***

5.2 ± 1.2***

4.7 ± 1.0***

OTM

0.3 ± 0.1

1.3 ± 0.3***

1.3 ± 0.4***

1.4 ± 0.6***

1.4 ± 0.5***

11 Me ₃ Sn(L3)

CTL (μm)

33.7 ± 1.1

39.7 ± 1.3***

44.9 ± 1.3***

41.8 ± 1.2***

41.0 ± 1.5***

% T DNA

2.7 ± 0.7

6.4 ± 1.2***

5.8 ± 1.2***

6.0 ± 0.1***

7.1 ± 0.4***

OTM

0.5 ± 0.1

1.4 ± 0.3***

1.5 ± 0.4***

1.3 ± 0.3***

1.9 ± 0.5***

12 Et ₂ Sn(L3) ₂

CTL (μm)

37.5 ± 1.2

42.1 ± 1.2***

40.8 ± 1.4**

36.6 ± 1.4

50.0 ± 2.0***

% T DNA

3.9 ± 0.85

5.2 ± 1.07

5.9 ± 1.2*

6.4 ± 1.16**

9.0 ± 1.7***

OTM

0.8 ± 0.2

1.3 ± 0.3

1.4 ± 0.4*

1.4 ± 0.3**

3.2 ± 0.4***